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Six women of childbearing age treated with carbamazepine (Tegretol; Novartis) for epilepsy during pregnancy received the drug in doses of 400 to 600 mg daily. The analyses of blood and urine samples at various times before and after the application of the drug did not show any significant deviations from the reference values for the women in normal pregnancy. The dosage regimen proved to be safe for the fetus. The plasma concentrations of the drug in the mothers on the last day of the third trimester were in the range of those observed in the nonpregnant state, and the infants were delivered without any evidence of neurological damage. The results of the investigations suggest that carbamazepine can be administered safely to pregnant women, and a dose reduction is not necessary in the majority of patients. However, the therapeutic range of the drug, which be359ba680
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